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https://www.griffithresearch.ca/news/2018/7/5/fiona-simpson-awarded-froum-masters-scholarship monthly 0.5 2018-07-06 https://www.griffithresearch.ca/news/2018/7/5/dr-griffith-featured-on-voir-grand monthly 0.5 2018-07-05 https://www.griffithresearch.ca/news/tag/Stem+Cell+Network+%28SCN%29 monthly 0.5 https://www.griffithresearch.ca/news/tag/Congratulations monthly 0.5 https://www.griffithresearch.ca/news/tag/Regenerative+Medicine monthly 0.5 https://www.griffithresearch.ca/contact daily 0.75 2024-03-18 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1537114392824-AQFXCJOO27STZFXWBWVA/harry-quan-486229-unsplash.jpg Contact https://www.griffithresearch.ca/home daily 1.0 2024-05-13 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1715613948919-R40PWLYFCBVKSP69309K/NCS_DSC03779.jpg Home - Natalia https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1715613965932-BBVETICJ8T9GI3GEHCE5/HG_IMG_6463.jpg Home - Hamid https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1715613986350-S2OI4QQMAP39USPKE2ZK/NT_20240412133752_IMG_8536.JPG Home - Neethi https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1530292195617-OOTW6TUCFWWDYSERW2V5/Eye.jpg Home https://www.griffithresearch.ca/corneal-implants daily 0.75 2021-12-25 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1613067542913-MCZLESYL6MQ20CF92O50/RHCIII-MPC.jpg Corneal Implants Patient corneas before and after grafting with RHCIII-MPC implants at last follow-up. Patients are divided into three groups based on their pre-operative diagnoses: infection (herpes simplex viral and fungal keratitis), burns (alkali and thermal) and other (failed graft and post-stroke neurotrophic keratitis). Post-operation, regenerated neocorneas from Patients 1 and 2 are mostly clear. In Patients 3 and 4, where stem cell deficiency is present, some superficial vessels concurrent with conjunctival invasion are seen. Patient 5 has a mostly clear cornea encircled by blood vessels but has invaded in one quadrant, while Patient 6’s cornea remains hazy. Patient 2 has an unrelated nasal pterygium. Islam et al. NPJ Regen Med. 2018:31;3:2. Reproduced under a CC BY 4.0 license. https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1613066181436-QQKEK5VWB3QEDMFWN0YX/RHCIII.jpg Corneal Implants - Slit lamp biomicroscopy images of the corneas of all 10 patients at 4 years after grafting with a biosynthetic implant. Fagerholm P, et al. Biomaterials. 2014;35(8):2420-7. Used under a CC BY-NC-ND 3.0 license. https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1613068341123-UNE8WNROU15WTPET5LU6/CLP-PEG.jpg Corneal Implants Jangamreddy et al. Acta Biomater. 2018 Mar 15; 69: 120–130. Reproduced under a CC BY 4.0 license. https://www.griffithresearch.ca/liqd-cornea daily 0.75 2021-02-11 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1613064399602-BDDGTJ9K4JG7VO6CTXCB/LiQD+Cornea.png LiQD Cornea https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1613068608200-6LEQL86XQPNYWZK3VR0W/LiQD+Cornea.jpg LiQD Cornea Biological evaluation of LiQD Cornea. (A) Immortalized HCECs cultured on LiQD Cornea hydrogels and control tissue culture plastic, showing that the hydrogels support epithelial growth. (B) Expression of T cell costimulatory molecules in BMDCs. Expression of CD40, CD80, and CD86 was measured by flow cytometry, and data are presented as a ratio of mean fluorescence intensity of the experimental samples to untreated BMDCs. LPS acted as a positive control for BMDC activation; *P ≤ 0.05 by Student’s t test. (C) Expression of pro-inflammatory M1 (CD86) and anti-inflammatory M2 (CD206) phenotypic markers at 4 and 7 days after exposure of naïve BMDM precursors to LiQD Cornea hydrogels. (D) Example of a human corneal perforation. (E) Postsurgical photos of rabbits immediately after injecting LiQD Cornea into a perforated cornea. The two-stepped surgically induced perforation can be seen. At day 2 after surgery, the air bubble placed under the cornea during surgery is prominent, indicating that the perforation was completely sealed. The perforated cornea was completed healed by 28 days after operation. Photo credit: Damien Hunter, University of Sydney. (F) Mini-pig corneas where the LiQD Cornea was tested as an alternative to a donor allograft, showing the gross appearance of the LiQD Cornea, syngeneic graft, and an unoperated eye at 12 months after surgery. Photo credit: Monika K. Ljunggren, Linköping University. McTiernan et al. Sci Adv. 2020:6(25);eaba2187. Reproduced under a CC-BY-NC license. https://www.griffithresearch.ca/may-griffith-2 daily 0.75 2021-12-25 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1530718970503-4SW1PITHFTT0M7AFM4NX/May.jpg May Griffith - Dr. May Griffith Professor Department of Ophthalmology, Faculty of Medicine, University of Montreal Centre de Recherche, Hopital Maisonneuve-Rosemont, Montreal, Quebec https://www.griffithresearch.ca/current-members daily 0.75 2024-08-23 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/23e93e60-68ef-466b-a200-167dd3418f5d/Lab_MM.jpeg Current members - Mona Moradi Institute of Biomedical Engineering, University of Montréal https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/4974ffc3-943a-4d6d-a9bb-579e98bbd0e5/NCS_DSC03779.jpg Current members - Natalia Callai Da Silva PhD Student Co-Supervisor : Dr. Sebastien Talbot I graduated my masters in 2020, in Health Sciences - Neuroscience, at Pontifícia Universidade Católica do Rio Grande do Sul. My research project is to investigate the nerve regeneration role of different drugs in corneas with an inflammatory model of Herpes simplex infection. For that, we use an in vivo model of cornea scarification or perforation, and we use the hydrogel developed in the lab to deliver the drugs. In the lab, I always listen to a podcast or audiobook. In my free time, I like to spend time with my friends, enjoy a good movie and explore the city - which can always lead to finding new coffee places and a chance to improve my spoken French skills https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/fc4ca93a-31cf-43f8-8e89-4ca460baf5bd/NT_20240412133752_IMG_8536.JPG Current members - Neethi C Thathapudi PhD Student Co-Supervisor : Dr. Marie Claude Robert I completed my Master’s in Life Sciences from the National Institute of Technology (NIT), India. After a 9-month long wait for visa, I finally began my research work at the Griffith Lab in Jan 2022. My research focuses on understanding the role of extracellular vesicles (EVs) in the context of cell-biomaterial interactions and viral infections. You will find me cooking and talking about philosophy, when I am not in the Lab. https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/f2f82717-32bc-49a3-b6a2-8e22f84d6906/HG_IMG_6463.jpg Current members - Hamid Goodarzi PhD Student Co-supervisor : Dr Christos Boutopoulous I did my Master’s at Tarbiat Modares University (TMU) Tehran in Biomedical Engineering. I started my PhD in Fall 2020 but came to Canada winter 2021. My Research Project is on Printing of Biomaterials for Cornea Regeneration, where I work with Dr. Christos Boutopoulos. I also work on developing Collagen-based Implants with Testing Different Sterility Methods for Corneal transplantation. My hobbies include hiking, playing volleyball and biking. https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/70d52d52-7fd5-454f-b6a3-c32cf1cb3b51/Lab_SM.jpeg Current members - Solange Muhayimana Institute of Biomedical Engineering, University of Montréal https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/6027c18f-fc52-468b-ba1c-9ffd8f41bc3a/MZ.jpg Current members - Mostafa Zamani ROUDBARAKI PhD Student Co-Supervisor : Dr. Christos Boutopoulous I earned my master's degree in chemistry from the University of Tehran and joined Dr. Griffith's group in Fall 2021, where I've been developing innovative hydrogels for treating alkali-burnt corneas. 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I am working on development of in vitro and in vivo models for neuronal delivery of nucleic acid vs peptide-loaded nanoparticles for cornea HSV-1 infection treatment I enjoy indulging in various hobbies such as exploring new recipes, reading novels, watching movies, playing chess, going for walks, and now, spending time with my little son. https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/79602891-8bcb-4117-99e2-4886a73ea303/Lab_Ines.jpeg Current members - Ines Barrakad Institute of Biomedical Engineering, University of Montréal https://www.griffithresearch.ca/publications daily 0.75 2021-12-25 https://www.griffithresearch.ca/past-members daily 0.75 2022-03-24 https://images.squarespace-cdn.com/content/v1/5b365abb85ede1b335f52b32/1633353472064-AZYTU99IGIIZKOFHQEJV/FCS_Sq.jpg Past Members - Make it stand out Dr. Fiona Simpson successfully defended her PhD thesis in January 2022. 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